الفهرس 
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Abstract
Summary
This is a prospective randomized study between January 2016 and September 2016, 150 adult patients presenting with distal ureteric stones of size 5 to 20 mm in which we divided them into three groups, each group contains 50 patients, using single dose of drug per day before bed time, continued until stone expulsion or for maximum two weeks.
Patients grouped .to.Silodosin.with.Prednisolone.(.group.A.).,.Silodosin.only.(.group.B.). and.Prednisolone.only (.group C.). Each one was given for a maximum of two weeks. In group A and C, 5 mg .of Prednisolone was given once daily. Stone expulsion rate, time to stone expulsion, analgesic use, follow-up and endoscopic treatment and adverse effects of drugs were noted. Statistical analyses were done using chi- square test, and analysis of variance
Stone size has high statistical significance with stone passage, time of expulsion and analgesic requirement.
The expulsion rates were not statistically different between groups A,B and C. The mean time to expulsion and analgesic use were significantly lower in groups A than group B ,it was statistically significant with group A and C .
Regarding to the side effects :
in group A : 3 patients had gastritis which started after 5 days or more from beginning of the treatment and resolved completely without any additional treatment in a period less than 2 weeks. Only 1 patient had increase in blood glucose level reaching 180 mg/dl and returned to the baseline 110 mg/dl after 10 days of discontinuation of the treatment, 3 patients had increase blood pressure readings starting after 5 days or more from beginning of the treatment, not exceeding 150/90 rising from baseline 120/80 and returned back to baseline in a period less than 10 days after discontinuation of the drug.
In group C : 3 patients had gastritis , 1 patient had increase blood pressure , 1 pt had increase blood glucose level
The most frequent adverse event with silodosin was a reduced or absent ejaculation , In group A : 18 patients ( 8 patients were distressed , 4 patients were not distressed and 6 patients were distressed but can wait for it’s improvement ) and in group B : 19 patients ( 10 patients were distressed , 4 patients were not distressed and 5 were distressed but can wait for it’s improvement ) ,