الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The early detection of Acute Kidney Injury after pediatric cardiac surgery can lead to improving protective and therapeutic interventions. The study included 30 Egyptian children aged 1 week to 204 months undergoing cardiopulmonary bypass (CPB) surgery. The venous blood was withdrawn from all patients at 2 hours preoperatively, as well as 2 h, and 24 h postoperatively for serial measurements of serum creatinine (S.Cr), serum urea, and plasma NGAL. Moreover, we measured S.Cr and serum urea levels during 48 h post-CPB. We classified patients according to creatinine criteria of Acute Kidney Injury Network into AKI (n=9) and non-AKI (n=21) groups. Plasma NGAL levels highly significantly increased at 2 h, and 24 h after surgery (p<0.001) in AKI group. However, neither S.Cr nor serum urea showed any statistically significant elevations at 2 h or 24 h after surgery but significant elevations were recorded later at 48 h after surgery (p<0.001). Plasma NGAL effectively predicted AKI early at 2 h after surgery with a sensitivity of 100.0% and specificity of 100.0%. This study showed that the measurement of plasma NGAL can serve as an early biomarker for detection of AKI following pediatric cardiac surgery compared with both serum creatinine and serum urea.