الفهرس 
Introduction
Diabetes mellitusOnly 14 pages are availabe for public view
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Abstract
Subclinical abnormalities of cardiac structure and diastolic function are commonly present in patients with diabetes. Multiple epidemiologic studies have demonstrated that diabetes mellitus (DM) increases the risk for the development of Heart Failure (HF). The incidence of HF increases in a stepwise manner with increasing the level of HbA1c. Pre-clinical diastolic dysfunction has been broadly defined as diastolic dysfunction in patients with normal systolic function, and no symptoms of HF. In our study, we enrolled 100 patients with newly diagnosed type II DM (within one year), between the age of 30 and 60 years, normotensive (blood pressure <130/80 mmHg) and clinically asymptomatic without evidence of heart failure (HF). They were 53 males and 47 females with a mean age of 50 ± 6 years. They were classified according to HbA1c level into two groups: group I with HBA1c > 8.1 and group II with HBA1c <8.1. Also, we re-classified the study group into another two sub-groups according to the presence or absence of diastolic dysfunction: group Y with diastolic dysfunction, group N with normal diastolic function. Baseline characteristics (Age, gender, BMI, WC and WHR), laboratory finding (FBG, 2hPPBG, KFTs and lipid profile) and echocardiographic finding (systolic function using Simpson’s biplane method and diastolic function using various parameters as mitral inflow, TDI and LA size and volume) were recorded in both groups. The study revealed high burden of diastolic dysfunction in group II (HbA1c > 8.1) DM population (E/e’ ratio and LAVI) were significant (p<0.05) with a higher degree of diastolic dysfunction in group II (p<0.05) and IVRT tends to be significant (P= 0.06). However, there were no differences between two groups in LV systolic function assessed by Simpson’s biplane method and LV systolic and diastolic volumes assessed by echocardiography. Total cholesterol and triglycerides were significantly higher in group II while high density lipoprotein was significantly lower in this group of patients. Subjects with diastolic dysfunction had higher levels of FBG, 2hPPBG, HbA1c, T.cholesterol, triglycerides and LDL as well as WHR in a statistically significant values (p<0.05). A total of 61 (61%) patients had diastolic dysfunction.