الفهرس 
EPILEPSYOnly 14 pages are availabe for public view
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Abstract
Objective: To select patients with drug resistant epilepsy (DRE) following up in Pediatrics Neurology Outpatient Clinic, Children’s Hospital, Ain Shams University who are candidates for epilepsy surgery and to detect the outcome of epilepsy surgery in such children as regards seizure control.
Methods: This prospective study was conducted over a period of 36 months and comprised of 3 stages. Stage 1 included selection of candidates for epilepsy surgery and preoperative evaluation. Evaluation included clinical assessment, seizure severity using Chalfont score, video EEG and MRI epilepsy protocol. Stage 2 included surgery phase where decision of surgery was made by a multidisciplinary team. Stage 3 included post-operative evaluation as regards seizure frequency, seizure severity using Chalfont score, Engel Epilepsy Surgery Outcome Scale and the International League Against Epilepsy (ILAE) outcome classification.
Results: seventeen patients with DRE underwent epilepsy surgery, 1 with Focal cortical dysplasia, 7 with GDD and Epilepsy, 1 with Idiopathic epilepsy, 2 with Lissencephaly type 1, 1 with neuroregression, 1 with Post anoxic cerebral palsy, 1 with Postencephalitic sequalae, 2 with Sturge weber syndrome and 1 with Tuberous sclerosis. As regards type of epilepsy surgery, 12 (70.6%) patients did partial corpus callosotomy, 1 (5.8%) Left frontal lobe lesion resection, 3 (17.7%) right anterior temporal lobectomy and 1 (5.8%) left occipital lobectomy. Results revealed significant decrease in seizure frequency and severity at 3, 6 and 12 months after surgery. As regards Engel Epilepsy Surgery Outcome Scale, number of patients with class I at 3, 6 and 12 months were12 (70.6%), 11 (64.7%) and 8 (47.1%) patients respectively. As regards the ILAE outcome classification, number of patients with class I at 3, 6 and 12 months were 11 (64.7.1%) 10 (58.8%) 7 (41.2%) patients respectively.
Conclusions: for this study we conclude that about 50% of patients who were suffering from DRE became seizure free after epilepsy surgery while about 40 % had seizure reduction over the period of 12 month postoperative. Further studies are warranted with a larger sample size and larger follow up duration.