الفهرس 
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Abstract
Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. It is the most common skin disease affecting 85% of young individuals worldwide and it usually manifests during puberty and worsens throughout adolescence. The pathogenesis of acne includes hormonal, inflammatory, and immunologic mechanisms. Survivin is a member of inhibitors of the apoptosis (IAP) protein family. The expression of survivin is undetectable or is found at very low levels in normal tissues, whereas it is found at relatively higher levels in various malignant tissues, embryonic and fetal tissues, and uncommonly in normal adult tissues, including skin. Survivin has been found to be increased in keratinocyte proliferative and inflammatory states, which are deeply involved in the pathogenesis of the acne lesions. This study was conducted to evaluate plasma survivin level in acne vulgaris patients compared to controls. Also, to study the relation of survivin level to the severity of acne. The study included 40 patients with acne vulgaris in addition to 40 matched age and gender healthy volunteers as a control group selected from Outpatient clinic of Dermatology, Mansoura University Hospitals, Mansoura. After obtaining a written informed consent, the cases were subjected to full history taking and clinical examination including general examination and full dermatological examination.