الفهرس 
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Abstract
This study was aimed to determine the antioxidant characteristics and hepatoprotective role of dietary pumpkin seed oil (Pepon®). The results showed that pumpkin seed oil produced a significant antioxidant activity in the prophylactic and treated groups as compared to the control (non treated) group. The obtained data showed that there were a significant decrease in serum cholesterol and triacylglycerol levels of rats prophylactic or treated with pumpkin seed oil at low and high doses (50&100 mg/kg b.wt.) compared to the control (non treated) group. In addition, the pumpkin seed oil had significant hepatoprotective effects on the liver. These findings were confirmed by the histopathological findings. There was a significant decrease of the liver enzymes (ALT, AST & ALP) in the groups which prophylactic and treated by pumpkin seed oil for one month before and after TAA toxicity, respectively. Liver enzymes were near to the normal when compared to the control group. Histopathological findings revealed mild pathological changes, which were less in severity compared to the control TAA -intoxicated group. Also, there were also a clear significant amelioration in serum creatinine and urea levels in all groups compared to the control group. Daily oral administration of pumpkin seed oil for one month to rats showed that the tested oil at all doses had no adverse effect on the blood criteria.