الفهرس 
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Abstract
Chlorpyrifos (CPF) is one of the most used OPs. It is used to control agriculture and household pests, flies and mosquitoes. CPF acts as an acetylcholinesterase inhibitor. Lead is a toxic metal that induces abroad range of physiological, biochemical and neurological dysfunctions in humans. Pb induces oxidative stress and disrupts the intracellular antioxidant balance through the generation of excess reactive oxygen species (ROS) in biological systems . *
Quercetin is a polyphenolic flavonoid compound. Moreover, owing to its high solubility and bioavailability, quercetin may also exhibit strong antioxidant activity after forming a complex or combining to form some novel preparations used for human health care.
The aim of the work was to explore whether quercetin affords protection against chlorpyrifos (CPF), lead acetate (PbA) and their mixture (CPF+PbA) induced hepatotoxicity and nephrotoxicity in male rats.
In this study eight groups (6 /each) of rats are assigned and treated as following:group I (control) was orally administered corn oil., group II was orally administered with a dose equal 50 mg/kg of body weight of quercetin., group III was orally administered with a dose equal 1.63 mg/kg of body weight of chlorpyrifos ., group IV was orally administered with a dose equal 10.8 mg/kg of body weight of lead acetate ., group V was orally administered with a dose equal 1.63 mg/kg of body weight of chlorpyrifos and 10.8 mg/kg of body weight of lead acetate,group VI was orally administered with a dose equal 1.63 mg/kg of body weight of chlorpyrifos and 50 mg/kg of body weight of quercetin., group VII was orally administered with a dose equal 10.8 mg/kg of body weight of lead acetate and 50 mg/kg of body weight of quercetin.