الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Ovarian cancer is the leading cause of death among all gynecological malignancies because of the silent nature of the disease and the asymptomatic presentation especially in the early stages of the disease. Early detection of ovarian cancer is the key to successful treatment as a result; attempts have been made to establish a screening tool for early detection of ovarian cancer.
One of those prognostic tools is the (IOTA-ADNEX) model which uses nine predictors. There are three clinical variables, age, serum CA-125 level, and type of center (oncology referral center vs other), and six ultrasound variables, maximal diameter of lesion, the proportion of solid tissue, more than 10 cyst locules, number of papillary projections, acoustic shadows, and ascites.
This work aimed to assess the performance of the IOTA-ADNEX Model in preoperative assessment of suspicious adnexal masses with correlation to the intraoperative findings and histopathological examination.
The current study was conducted on 150 cases with suspicious ovarian masses according to clinical data and RMI2 in the Gyne-Oncology unit of Elshatby University Hospital. All subjects underwent history taking, Clinical examination, US imaging, and calculation of RMI2 and IOTA. The optimum surgical staging was done for cases with suspicious malignant adenxal masses, with histopathological examination of surgically resected ovarian masses or biopsies obtained from ovaries.
Among the studied cases the Mean age was 49.9 years, and the incidence of tumor occurrence in all studied groups was higher in the postmenopausal females than the premenopausal females.
In the current study the medical history of the malignant tumors group (n=110), 34 females had a history of chronic disease, 22 were hypertensive, and 18 females were diabetic. Only 22 females had a past surgical history.
As regards the obstetric history, the highest level of previous cesarean section and abortion was in the patients with tumor grade II-IV where it was 29.2%, and 12.5 respectively.
As regards the ultrasonographic findings, the Presence of locules >10, papillary projection >3, ascites, and lesion bilaterality were more common in the tumor grade II-IV with percentage 16.7%, and 33.3%, 41.7%, and 33.3% respectively.
In agreement with many studies, most of the studied cases (81.3%) showed elevated CA level. The CA level was elevated in the benign tumors, borderline tumors, tumor grade I, and tumor grade II-IV that represented 75%, 57.1%, 83.3%, and 91.7% respectively.
Using FIGO staging system, the malignant tumors were distributed as 14 borderlines, 48 malignant stage I, and 30 malignant stage II, 18 malignant stage III, and 2 malignant stage IV.