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Abstract Benign prostatic hyperplasia (BPH) is one of the most common causes of lower urinary tract symptoms in elder men (1). Over the last few decades, transurethral resection of prostate (TURP) has been the gold standard technique for surgical treatment of benign prostatic hyperplasia (2). As monopolar TURP was the 1st leading technique for resection but still has disadvantageous, such as TURP syndrome, bleeding and failure to complete the procedure without disappointing outcomes (3). Bleeding (4) has been one of the most fearful complication with overall incidence varying between 0.5 to 8 % (5). Intractable hemorrhage may lead to life threatening situations especially when capsular perforations are encountered demanding surgical exploration or arterial embolization (6). Prophylactic measures have been employed to reduce peri- operative bleeding including preoperative 5α-reductase inhibitors administration. Finasteride and dutasteride can block the conversion of testosterone to dihydrotestosterone (DHT) and has been used to treat BPH and BPH-related hematuria. Many reports have confirmed the efficacy of finasteride or dutasteride (7) in reducing perioperative bleeding in patients undergoing TURP. |