الفهرس 
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Abstract
Background: Asthma is an inflammatory disorder based on an improper induction of immunity by environmental aeroallergens. It is characterized by bronchial hyperactivity, reversible airway obstruction, and mucous overproduction (Bierbaum and Heinzmann, 2007). House dust mites (HDM) are a common source of airborne allergens worldwide and it’s considered that HDM sensitization influences > 15-20% of population in industrial countries (Jacquet, 2013). The most common sensitizing strains of HDM represented in studied samples in Egypt are Dermatophagoides pteronyssinus and Dermatophagoides farina (Hossny et al., 2014). Even with increased knowledge and understanding of asthma as a disease, it only remains controllable with proper treatment. Classification of asthma according to disease severity defined level of asthma as (mild, moderate, severe) according to treatment steps (GINA, 2018). Materials and Methods: we selected sixty asthmatic patient with history of atopy. The patient subdivided into two group by skin prick test; group1 was sensitive to house dust mite HDM (D pteronyssinus or D farina) and group2 was not sensitive to HDM. Then we assessed the severity according to treatment steps and determine the profile of asthma in sensitive HDM groups. Results: Our results revealed that sensitization to house dust mite increase the severity of asthma; decrease the ability to control asthma; asthmatic patient sensitive to house dust mite had a profile of cough asthma, and associated with allergic rhinitis. Conclusion: We concluded in our studied that HDM sensitization is associated mainly with cough asthma phenotype and allergic rhinitis; HDM sensitization increases asthma severity and decreases the ability to control asthma symptoms