الفهرس 
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Abstract
An efficient therapeutic approach for osteoarthritis (OA) is yet to be discovered. In the current study, we evaluated coadministration of nanocurcumin (NCur) and platelet rich plasma (PRP) as a potential therapeutic strategy for treating experimentally induced osteoarthritis.
Sixty male albino rats weighing 180± 20 gm. were divided into 5 groups, 12 rats each. The first group was injected with saline (Control group). To induce osteoarthritis in the other four groups, rats were injected with 2 mg of monosodium-iodoacetate (MIA) in a total volume of 50 ul of saline. All injections were done in the right knee joint through the infra-patellar ligament to induce osteoarthritis. Two weeks after injection of MIA, one group was left untreated (Osteoarthritic group) and another group (third group) received 200 mg/kg NCur through gastric intubation for 14 consecutive days. A fourth group was intra-articularly injected with 150 ul activated PRP. The final group was concurrently treated by both PRP injection and NCur gavage.
Assement of knee joints was achieved through histological, immunhistochemical and radiological examination beside serum inflammatory cytokines were analyzed after 15, and 30 days post treatment.
Fifteen days post treatment, The level of these inflammatory cytokines in the treated rats significantly decreased compared to the osteoarthritic group with the lowest values were observed in the NCur +PRP.
Radiological examination of OA group showed disappearance of joint space with sclerosis, osteophyte formation and roughness of articular surfaces, This x-ray image was improved in all treated groups, but results more pronounced in group treated by (PRP+ NCur) that showed normal joint space, little or resorbed osteophyte and smooth articular surfaces.