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Abstract Sepsis is a life-threatening condition that occurs when the body’s response to infection causes tissue damage, organ failure, or death.Internationally, an estimated 30 million people develop sepsis and 6 million people die from sepsis each year.Resuscitation with intravenous fluid is the first line of acute circulatory support in critical care. The current practice and evaluation of fluid challenges in critically ill patients seems to be arbitrary, dose not seems evidence-based and could be harmful. |