الفهرس 
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Abstract
ABSTRACT: This study targeted two medicinal plants used in traditional folk medicine in Saint Catherine Protectorate in the south Sinai in Egypt, one of which is Capparis spinosa plant and the other is the Globularia arabica plant. The active constituents of the studied plants were extracted using different extraction solvents and their phytochemical constituents were estimated then screened for their antioxidant and antimicrobial potential. 80% methanol extract and petroleum ether extract for Capparis spinosa as the highest in antimicrobial activity and 80% ethanol extract and petroleum ether extract for Globularia arabica also as the highest in antimicrobial activity were selected in order to separate the essential oils and analyse them using GC/EIMS and effective groups have been detected for them using a FTIR device. 80% methanol extract for Capparis spinosa as the highest in its antioxidant and antimicrobial activity and 80% ethanol extract for Globularia arabica as the highest in its antioxidant and antimicrobial activity were selected to separate them chromatographically using Amberlite XAD-16 resin, and Thin layer chromatography. The 80% methanol extract for Capparis spinosa plant resulted in five fractions and six fractions resulting from 80% ethanol extract for Globularia arabica. The obtained fractions were also screened for their antioxidant and antimicrobial activity. The fractions having elevated antimicrobial and antioxidant activity were analysed using LC-MS-MS for structural elucidation of the active constituents responsible for their activity. The results obtained by LC-MS-MS for the most powerful fractions verified their rich and diverse phenolic profiles. Indeed, an important of flavonoids and flavonoid glycosides were identified and these rich profiles probably responsible for higher activities of these fractions. Through the results obtained, these plants could be used to provide antioxidant and antimicrobial natural compounds as alternatives to antibiotics for antibiotic resistant strains.