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Abstract The third stage of labor refers to the interval from the delivery of the baby to the separation and expulsion of the placenta. The major complication associated with this period is postpartum hemorrhage (PPH), which is the most common cause of maternal morbidity Current study aim to evaluate the use of intraumbilical vein injection of oxytocin versus intravenous injection of oxytocin with active management of the third stage of labor in reducing blood loss and length of the third stage.It is Open labeled prospective randomized controlled trial We selected (300) pregnant women undergoing vaginal delivery who did not have risk factors for postpartum hemorrhage randomly amongst pregnant women at Manfalout hospital of reproductive health , then we divided them randomly in to two equal groups Study group (A) - patients of this group received intraumbailical vein oxytocin 10 units of oxytocin diluted in 10 ml of normal saline) in the umbilical vein proximal to the site of umbilical cord clambing. Control group ( B) - patients of this group received 10 units of oxytocin intravenous infusion immediately after delivery of the baby .after cord clamping immediately after delivery of the baby and placenta delivery by controlled cord traction In total , 300 women who underwent vaginal delivery were enrolled in our study, 150 women were in group A ( received intraumalical oxytocin injection and 150 women were in group B ( received intravenous oxytocin injection)There was no statistically significant difference between the two group of women in patients age , gestational age , parity , fetal weight and placenta position. However, there was a significantly lower blood loss and shorter duration of third stage of labour in women of group A (intraumbalical oxytocin injection ) than women of group B ( intravenous oxytocin injection)We concluded that the method of intra-umbilical injection of oxytocin immediately after the delivery of the baby, significantly reduced the duration of the third stage of labour and the amount of blood loss in the third stage of labour as compared to the intravenous oxytocin. We need large randomarized trial to implement its use in the active management of third stage of labour. We recommend study between intramuscular method and intravenous method. Hence, the results of the review are applicable in under resourced settings where complications of third stage of labor are common and facilities for immediate blood transfusion and surgical intervention are limited |