الفهرس 
المقدمةOnly 14 pages are availabe for public view
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Abstract
Patients with intradialytic hypertension (IHTN) have an increased risk for hospitalizations and mortality. The pathogenesis of IHTN is not well understood. HD patients suffer also from intradialytic hypoxemia may be due to fluid overload, impaired respiratory function and ventilation–perfusion mismatch which are potential causes of intradialytic hypoxemia. Hypoxemia is thought to stimulate the blood pressure (BP) elevation by inducing a sympathetic response, endothelin secretion, consecutive vasoconstriction and finally IHTN.
The aim of this work was to study association between intradialytic hypertension and intradialytic arterial oxygen saturation in regular hemodialysis patients.
This is a prospective observational study that analyzed SaO2 and BP changes during hemodialysis (HD) sessions in 76 regular HD patients over 6 months. Patients were divided into 3 groups: group A; patients without intradialytic hypertension (Non-IHTN) in which intradialytic SBP change <10 mmHg, group B; patients with intradialytic hypertension (Non-PIHTN) which defined as intradialytic SBP change ≥ 10mmHg and group C; patients with persistent intradialytic hypertension (PIHTN) which defined as intradialytic SBP change ≥ 10mmHg over 6 months..
Groups B and C patients had a highly significant increase in pre-dialysis, intra-dialytic and post-dialysis SBP levels compared to group A (P˂0.001). Groups B and C patients also showed a highly significant DROP in pre-dialysis, intra-dialytic and post-dialysis SaO2 compared to group A (P˂0.001). There were highly significant negative correlations between the pre-dialysis, intra-dialytic and post-dialysis SaO2 and intradialytic SBP change elevation (P˂0.001). It was found that the reduction of the pre-dialysis and intra-dialytic SaO2 < 92.5% and 90.5% respectively could be predictors of intradialytic SBP increase (P˂0.001).