الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 109 |  |  |
| | | from | 109 | | |
Abstract
SUMMARY
N
eurodegeneration is now thought to play a major role very early in diabetic retinopathy. Research has shown that neurodegeneration occurs in very early stages of the disease. At present, there is enough information available to suggest that neural apoptosis precedes overt vascular abnormalities. However, subtle undetected vascular defects might exist before or at the same time that the retinal neurodegenerative process occurs in DR, and these vascular changes may have secondary repercussions for neurons.
OCT provides structural information and is fast, requiring no preparation of the patient; the output is immediately available. Current measurements of macular or peripapillary thickness provide useful quantitative data to assist in diagnosis and in monitoring the progress and any treatment of eye disease.
The purpose of our study is to evaluate neuro-degeneration in the macular (outer retinal layer thickness and ganglion cell complex layer thickness) are of patients with type 2 DM without diabetic retinopathy (i.e., retinal vascular alterations or macular edema) using optical coherence tomography.
This study was done on 60 eyes of 60 patients who were randomly selected and agreed to participate in the study divided into 30 eyes of normal healthy individuals and 30 eyes of diabetic patients
Full history was taken from the patient and was subjected to measurement of HbA1c and crareful ocular examination including BCVA, IOP, anterior segment examination, pupillary reflexes and posterior segment examination using indirect ophthalmoscopy and slit lamp biomicroscopy.then all patients were examined by OCT for measurement of outer retinal layer thickness and ganglion cell complex thickness.
The results of the current study revealed a statistically significant thinning of the outer retinal layer thickness and ganglion cell complex in the diabetic patients without diabetic retinopathy in comparison to the control.