الفهرس 
Chemical penetration enhancers
MATERIALS AND METHODSOnly 14 pages are availabe for public view
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Abstract
Enhanced local analgesia and/or local anesthesia can be achieved by simultaneous skin application of analgesics with local anesthetic drugs. Accordingly, the primary aim of this work was to optimize the simultaneous transdermal delivery of an analgesic and a local anesthetic. Vesicular delivery systems provide diverse carrier systems with characteristics that can be tailored by controlling their composition in addition they can carry more than one drug simultaneously thus the study employed niosomes as potential carrier for the selected drugs as single components and as binary systems. Taking into consideration that the combination of analgesic and local anesthetic may result in physical or chemical interactions including eutectic and/or complexation which can subsequently modulate the transdermal drug delivery potential of the drugs. This may hamper the development of effective delivery system for co-transport of the analgesic and local anesthetic through the skin after topical application. Thus, the study was extended to investigate the potential of any interaction between the selected drugs which may alter their skin permeability.