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العنوان
The role of epigenetic modifications on the expression pattern of cytochrome P450s in hepatoma cells /
المؤلف
Khedr, Sherine Elsayed Mohamed.
هيئة الاعداد
باحث / Sherine Elsayed Mohamed Khedr
مشرف / Mohamed Hessien Mohamed
مشرف / Elsayed Ibrahim Elsayed Salim
مشرف / Thoria Khalifa Donia
الموضوع
Biochemistry.
تاريخ النشر
2020.
عدد الصفحات
157 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
13/12/2020
مكان الإجازة
جامعة طنطا - كلية العلوم * - كيمياء حيوية
الفهرس
Only 14 pages are availabe for public view

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Abstract

Background and objectives: There are a considerable interest in the role of epigenetic modulations in the regulation of Cytochromes P450s (CYPs). These genes are involved in drug metabolism, the responsiveness of cancer cells to chemotherapeutics and the inter-individual variations in drug responsiveness. This study was designated to investigate the effect of DNA methylation and histone acetylation on the responsiveness of hepatoma cells to anticancer drugs. Also, to investigate the potential of usability of hepatoma cells as a background in vitro model in pharmacogenetics studies.