الفهرس 
Chemistry of quinazolineOnly 14 pages are availabe for public view
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Abstract
Quinazoline is an organic compound with the formula C8H6N2. It is
an aromatic heterocycle with a bicyclic structure consisting of two fused sixmembered
aromatic rings, a benzene ring and a pyrimidine ring. It is a light yellow
crystalline solid that is soluble in water. Also known as 1,3-diazanaphthalene,
quinazoline received its name from being an aza derivative of quinoline. Though the
parent quinazoline molecule is rarely mentioned by itself in technical literature,
substituted derivatives have been synthesized for medicinal purposes such as
antimalarial and anticancer agents. Quinazoline is a planar molecule. It
is isomeric with the other diazanaphthalenes of identified.
In this investigation, when 2-(4-oxo-2-phenylquinazolin-3(4H)-
yl)acetohydrazide (1) was treated with phenylisothiocyanate under reflux
afforded 2-[2-(4-oxo-2-phenylquinazolin- 3(4H)-yl)acetyl]-Nphenylhydrazine-
1-carbothioamid (2) in 80% yield (Scheme 1).