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العنوان
Preparation, Structural characterization and Study biological activity of metal complexes of modified paracetamol drug /
المؤلف
Ahmed, Reham Ali Saied.
هيئة الاعداد
باحث / ريهام على سيد أحمد هشهش
مشرف / عبده سعد الطبل
مناقش / أسامة أحمد فؤاد
مناقش / سوسن عبدالهادي أحمد حسن
الموضوع
Molecules - Models Industrial applications. Chemistry, Physical and theoretical.
تاريخ النشر
2020.
عدد الصفحات
221 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Analytical Chemistry
تاريخ الإجازة
4/11/2020
مكان الإجازة
جامعة المنوفية - كلية العلوم - قسم الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

This work is composed of three main chapters
I- Aim of the work
The work aimed to prepare and characterize new paracetamol metal complexes to study their biological activity against bacteria and fungi hoping to explore some effective compounds to be used in treatment of some microbial diseases.
II- Introduction
This chapter includes an overview of previous researches for complexes of Schiff –base ligands and their applications.
III- Experimental
This chapter contains the chemical and instruments used in Practical part of thesis as follow:
1) Preparation of the Schiff –base ligand and its metal complexes.
2) characterization of the ligand and its complexes using:
 Physical techniques such as molar conductance, magnetic susceptibility and melting point.
 Elemental analyses (C, H, N, Cl and M).
 Spectral techniques as IR, UV- Vis., 1HNMR, mass spectra and ESR measurements.
 Thermal techniques as DTA and TGA
3) Measurement of Antibiological activity.
IV- Results and discussion
This chapter includes characterization of the ligand and its metal complexes. The complexes were prepared and characterized by elemental analyses, IR, UV-Vis spectra, Magnetic moments, Conductivity, 1H-NMR and Mass spectra, Thermal analyses (DTA and TGA) and ESR measurements.
The elemental analyses, spectral data reveal that, the formed complexes are colored, stable in the air and soluble in solvents such as DMF, DMSO and ethanol.
The antibacterial activity was tested against two bacterial strains; Gram-positive Staphylococcus aureus as well as Gram-negative Escherichia coli strains. The complexes were also subjected to antifungal activity against Aspergillus flavus and Candida albicans. Complex (4) appeared in nano size and shows high activity against bacteria and fungi.