الفهرس 
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Abstract
Peripheral neuropathy can leads to multiple symptoms like numbness s, pain , itching, burninig sensation, and muscles weakness, it is usually affecting upper and lower limbs spescially hands ,feet, forearms and legs.
Peripheral nerves acting as an important alarm for tissues to can face the dangerouses which is facing by them ,it acting as A defence army for any harmful agents
Diabetes Mellitus is the most common cause of peripheral neuropathy.
Jean martin was the first one who descriped this disease, by year 1868.
Until the development of antibiotics ,the syphilis was the most common cause of peripheral neuropathy.
The pathophysiology of charcot Arthropathy can be explained by one of the two following theory,
Neurotaraumatic theory ,which explains the occurance of charcot arthropathy due to multiple and fine fractures which can caused by fine and multiple dual trauma ,due to absence of body defencing alarming system.
Neuro vascular theory ,which explains occurance of charcot Arthropathy due to vasodilatation of blood vessels which leads to calcium absorption and weakness of the bones which become so soft and available to fractures.