الفهرس 
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Abstract
Background: Giant Cell Tumor of Bone was first described by Cooper in 1818. Giant cell tumor of bone is a rare, benign, locally aggressive skeletal neoplasm abundant with giant
cells that is often seen in young adults and may rarely present with pulmonary metastases.
Aim of the Work: To evaluate if the presence of a pathological fracture affects local recurrence rates in the patients with a GCT of the bone through a systematic article review of studies conducted in English with providing quantitative and qualitative assessment of previous studies and meta-analysis.
Methodology: This review was done using standard methodology outlined in the Cochrane Handbook and reported the findings in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement guidelines. The review was restricted to RCTs, clinical trials, cohort and comparative studies, either prospective or retrospective, which studied the outcome of Pathological fracture group versus No fracture
group of GCT patients.
Results: Meta-analysis showed that overall recurrence rate in fixed and random-effects models were (22.7% and 21.6% respectively).
Conclusion: Age, gender, tumor location, Campanacci, grade, and pathologic fracture had no statistically significant influence on local recurrences of GCTB. Soft tissue extension
and intralesional curettage of surgical methods were independent risk factors of local recurrence of GCTB. The results of the present study suggested that compared with
curettage and wide section, treatment of GCTB by extensive curettage could provide the favorable local control and functional recovery. Our study might provide potential guiding
significance for the eligible treatment of GCTB in the future.