الفهرس 
Systemic Lupus ErythematosusOnly 14 pages are availabe for public view
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Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disorder that manifests
as a chronic inflammatory disorder with multisystem involvement. The presentation is
highly variable, the disease follows a relapsing and remitting course, and although
standardized treatment has improved the short- and medium-term outlook, long-term
prognosis remains poor in children with lupus with major organ involvement.
Red blood cell distribution width (RDW), obtained from a standard complete
blood count (CBC). It is a measure of the variability in size of circulating erythrocytes
and is indicated as the coefficient of variation of the erythrocyte size. Red blood cell
distribution width (RDW) is a parameter routinely tested to describe the heterogeneity
of red blood cells.
A recent study has also shown that RDW was increased in patients with
systemic lupus erythematosus (SLE). However, whether RDW has prognostic value in
assessing the disease activity of SLE and its complications such as lupus nephritis
remains unknow.
Therefore, this study aims to determine the level of Red blood cell distribution
width (RDW) in children with systemic lupus erythematosus and its clinical importance
as a potential index to assess the disease activity.
This cross-sectional study was conducted on 40 children, they Attending to
Pediatric Department, Faculty of Medicine, Menoufia University during the period of
study from August 2018 till October 2019. All subjects’ groups were classified into two
groups as:
Patient group: included 20 systemic lupus erythematosus children. Control group:
included 20 apparently healthy child of matched age and sex.
All the included patients were subjected to full history taking, complete physical
examination and the following laboratory investigation were done:
Complete blood count (CBC):
Kidney functions: including blood urea and serum creatinine.
Liver function test: including Serum glutamic pyruvic transaminase (SGPT), and
Serum glutamic oxaloacetic transaminase (SGOT).
ESR, C3, C4, ANA, anti-ds DNA antibodies
Red blood cell distribution width (RDW).
Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score was
used to assess disease activity of based on clinical symptoms and laboratory results
according to 24 items for 9 systems, scored if present within the last 10 days. Scores
range from 0–105 points.
Results of the current study could be concluded as follow:
There was no statistically significant difference between SLE patients and healthy
control groups as regard age (p=0.68), family history (p=1.00) and Sex (p=0.633).
Also, all of the studied subjects hadn’t family history about the disease.
Most of SLE patients had very high activity (60%), followed by high activity (30%),
then moderate activity (10%).
Mean SLEDAI was equal (30.75±18.40).