الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 71 |  |  |
| | | from | 71 | | |
Abstract
The major causes of dysphonia after unsuccessful microlaryngeal surgery are adhesions and scarring. Once a vocal fold scar has formed, treatment becomes an extremely difficult problem.
In the future, resection of vocal fold lesion may be followed with a simple injection of growth factors or stem cells to decrease scarring and to restore the layered architecture of the vocal fold.
Platelet-rich plasma (PRP) has gained interest over the two last decades, mainly because of its role in regenerative medicine. However, its use in ENT is not yet common and its application needs further studies.
PRP has the advantage of being an autologous product. Besides its high platelet concentration, PRP contains a high concentration of growth factors that are useful for wound healing and epithelization.
Several studies on animals concluded that PRP has favorable histological outcomes regarding the healing of vocal fold injuries. They recommended further clinical studies to assess the effect of these findings on the functional outcomes.
The work aims to assess the role of intraoperative local application of the platelet-rich plasma (PRP) gel in the improvement of quality of voice after microlaryngeal surgery.
The study design is a prospective comparative study which includes 40 patients undergoing microlaryngeal surgery for benign vocal fold lesions in the Department of Otorhinolaryngology-Head &Neck surgery, at the Main Alexandria University Hospital.
The assessment of voice was performed by videostroboscopy and acoustic analysis. One assessment was performed preoperatively and three other follow-ups were measured at 2 weeks, 1 month, and 3 months. Patients were randomly categorized into 2 groups; each group included 20 patients. group (A) was the study group subjected to microlaryngeal surgery for benign vocal fold lesions followed by intraoperative application of PRP gel. group (B) was the control group (without the application of PRP gel).
Our data have demonstrated that all the stroboscopic and acoustic parameters showed significant improvement in comparison to the preoperative assessment in both groups.
When comparing both groups, there were significant differences regarding jitter percent, shimmer, and NHR in the third postoperative follow up. group (A) showed better improvement regarding these parameters.