الفهرس 
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Abstract
Aim of the work:
We aimed to verify the association between cardiac dysfunction and serum ferritin level with unfavorable outcomes in pediatric sepsis.
Results
Fever was the most common presenting complaint among studied cases followed by tachypnea.
The diagnoses of the studied cases were three main categories: pneumonia, central nervous system infection and Gastro-enteritis, the etiology of increase the risk of pneumonia may include environmental factors, genetic susceptibility, and ethnic causes.
There was highly statistically significant difference between day of admission D1 and third day as regard to C-reactive protein with median value of CRP was higher on the day of admission compared to third day.
There was highly statistically significant difference between day of admission D1 and third day as regard to serum ferritin level with median value of Ferritin level was higher on the day of admission compared to third day.
Serum Ferritin level was significantly higher among non-survivor’s septic cases than survivor’s septic cases.
Cardiac dysfunction (EF<55%) was present among 47.5% of the studied cases.
Ejection fraction% was significantly lower among non-survivors than survivors septic.
Number of cases died with cardiac dysfunction was higher than that with no cardiac dysfunction.
Serum Ferritin level was significantly higher among cases with cardiac dysfunction than cases without cardiac dysfunction.
There were statistically significant positive correlations between serum ferritin level at day of admission and Capillary refill time, ALT, PT, and Creatinine. There were statistically significant positive correlations between serum ferritin level on day of admission and duration of Mechanical ventilator (hrs) value, duration of inotropes (hrs) and maximum inotropic score ,While there was no statistically significant correlation between serum ferritin level on admission and duration of PICU admission (days).
There was significant difference between cases with cardiac dysfunction and those without cardiac dysfunction as regard to duration of mechanical ventilation (hr.), duration of inotropes (hr.) and maximum inotropic score while there was no statistically significant difference between cases with cardiac dysfunction and those without cardiac dysfunction as regard to duration of PICU admission (days).
The mortality rate was 60% among cases. Factors found to be significantly associated with mortality by univariable analysis were entered the multivariable model to detect the significant predictors of mortality, cardiac dysfunction and serum ferritin were found to be predictors of mortality. Patients with cardiac dysfunction were more likely to die than patients without cardiac dysfunction), the increase in serum ferritin was associated with increase in the odds of child to die.