الفهرس 
Chapter I: Introduction and literature surveyOnly 14 pages are availabe for public view
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Abstract
Ibuprofen (IBU) is a poorly water-soluble non-steroidal anti-inflammatory drug it was finally patented in 1961 and this drug was first launched against rheumatoid arthritis in the UK in 1969 and USA in 197. The low aqueous solubility of ibuprofen limits the expected therapeutic outcome of IBU in pharmaceutical dosage form. Therefore, developing of advanced drug delivery system to control the release percentage of it through hydrogels based on β-CD by the formation of the β-cyclodextrin Ibuprofen inclusion complex (β-CD/IBU). Several modifications have been suggested to enhance its complexation efficiency with the drugs and to reduce the quite high cost of the β-cyclodextrin polymer. This involved integration or grafting its structure with the hydrophilic monomer (e.g. Itaconic acid, and ε-caprolactone). Additionally, the polymerization of β-cyclodextrin with other polymers or monomers increases solubility and bioavailability. Clay minerals have excellent adsorption properties, which can be attributed to their large surface area. This property makes them important candidates for adsorption or fixation of drug molecules, polymers, virus, bacteria and other substances to their surface.
In this study beta-cyclodextrin-grafted-Itaconic acid (β-CD-g-PIA), and beta-cyclodextrin-grafted-ε-caprolactone (β-CD-g-PCL) were synthesized by graft copolymerization in aqueous media. Polymerization was done at constant temperature in an oil bath. But modified drug carrier based on montmorillonite via miniemulsion echnique. Polymers or modified montmorillonite were characterized by Fourier transform infrared spectroscopy (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR) thermogravimetric analysis (TGA), X-Ray powder diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) techniques.
Keywords: β-cyclodextrin; Itaconic acid; ibuprofen; ε-caprolactone; ring-opening polymerization; In vitro drug release; Montmorillonite; Cetyl trimethyl ammonium bromide (CTAB); miniemulsion technique.