الفهرس 
Chapter 1 IntroductionOnly 14 pages are availabe for public view
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Abstract
Nanocommunication is a significant technology for the interconnection of nanomachines which
is exploited for realization nanonetworks concept. This technology aims to design and develop
the nano-scale communication capabilities for groundbreaking the applications of medical,
industrial and environmental. There are various nanocommunication systems, however
molecular communication (MC) is the promising technique for interconnection such
nanomachines. One of the forms of molecular communications is the wireless communication
based on Forester resonance energy transfer (FRET) phenomenon which is observed among
fluorescent molecules. In fact, FRET is a short-range nonradiative energy transfer mechanism
between fluorophores, which provides reliable wireless communication mechanism, with highrate to connect fluorophore-based photoactive molecular nanodevices. Various essays have
reported that, FRET is significantly employed in a variety of biomedical applications, cell-to-cell
interactions, and protein folding/unfolding and enhanced optical bioassays. In a consequence the
current thesis focuses on the nanocommunication-based FRET phenomenon.
In the current thesis, we present an interdisciplinary survey for nanocommunication technology
in various molecular networks; the principles/features of MC and the main comparison with
conventional communication schemes are presented. Inspiration by biological cell-to-cell
communication, we propose an approach for synesthetic relay transport proteins (RTP)-based
facilitative diffusion (FD) in order to facilitate the transmission of therapeutic drug from
extracellular environment towards blood vessels through plasma membrane. We actually apply
the concept of relay node in the conventional communication to design the molecular networkbased proposed approach. The structure of the molecular nanonetwork consists of three
nanomachines-labeled by fluorescent molecule (sensor as transmitter nanomachine, relay
nanomachine and actuator nanomachine as receiver nanomachine) to accomplish FRET
nanocommunication. Subsequently, we evaluate the performance of the approach in terms of
channel capacity and efficiency of information transfer. We also perform a performance
comparison of molecular nanonetwork with and without the proposed RTP.
On the other hand, Internet of Biological Nano Thing (IoBNT) is a novel paradigm that is
emerged in a similar manner of IoT. We propose a molecular communication (MolCom) system
can be jointed with IoBNT paradigm in order to interconnect a macroscale network (i.e., Internet
cyber domain) with nanonetwork (i.e., biological intra-human body). We design a feasible
downlink/uplink biocyber interface for this paradigm. In the downlink (from Internet to targeted
nanonetwork), the biocyber interface transduces electromagnetic (EM) signal to biochemical
signals, and thus with the help of mobile MolCom system based on FRET nanocommunication,
the drug information delivers to the diseased cell within the targeted intra-body nanonetwork. In
the uplink, the MolCom system consists of embedded sensor/actuator nanonetwork to detect the
biochemical changes in the targeted cell, and hence biocyber interface transduces the biochemical
signal to EM signal. The performance analysis of the proposed IoBNT system is numerically
investigated through MolCom system-based FRET while the performance evaluation is evaluated
by employing spreading epidemic scheme in terms of successful probability of drug delivery,
channel capacity, average drug-delivery time, and throughput. The simulation results show that
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the proposed IoBNT is a promising paradigm for smart drug delivery system and its performance
is mainly based on the nanostructure and the characteristic of molecular nanomachines in the
targeted nanonetwork.