الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is characterized by organ dysfunction arising from the effects of chronic hyperglycaemia. The chronic complications of diabetes are classified as macro and microvascular depending on the underlying pathophysiology. The microvascular triad of retinopathy, nephropathy and neuropathy is unique to diabetes. Inflammation plays an essential role in the progression of diabetic microvascular complications. Recently, new markers have been studied in the pathogenesis of diabetes and its complications such as progranulin. Progranulin also seems to be a reason for diabetic microangiopathy and its severity. The aim of this study was to study the relation between serum Progranulin level and microvascular complications in subjects with type 1 diabetes mellitus.
This case control study was conducted on 80 adult subjects ( >18 years) divided into three groups: group A included 40 patients with type 1 diabetes with disease duration more than 5 years who are more likely to have diabetes complications with mean age 25.88 ±7.10, group B included 20 patients with newly diagnosed type 1 diabetes (disease duration less than one year) who are unlikely to have diabetes complications with mean age 25.20 ± 5.31 and group C of age and sex matched 20 healthy subjects as a control group. T1DM subjects were recruited from the outpatient clinic of the Diabetes and metabolism unit at Alexandria Main University hospital. Patients with type 2 DM, malignancy, acute trauma, recent inflammatory disease and patients with degenerative disease of nervous system were excluded from the study. Moreover, pregnant females were also excluded.