الفهرس 
Introduction & RationaleOnly 14 pages are availabe for public view
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Abstract
Alopecia areata (AA) is a nonscarring hair loss disorder with an unpredictable course and a wide spectrum of manifestations. It affects both sexes equally (L. LY et al., 2016)
AA is usually diagnosed clinically by the characteristic narrowing of the hair shaft near the scalp (exclamation mark hair). Histopathological studies may be required in some cases in which the lesions reveal peribulbar lymphocytic infiltration.The infiltration consists of CD8+ T cells in the follicular epithelium and CD4+ T cells around the hair follicles (HFs) ( F. Rajabi et al., 2018)
Interleukin 16 (IL-16) is a potent anti-inflammatory cytokine that is secreted by a variety of cell types such as lymphocyte and epithelial cells. This CD4 co-receptor specific ligand is a multi-functional mediator that initially determined as a lymphocyte chemo-attractant cells (LCF). It can also attract activated T CD4+ cells and re-circulate and activate antigen presenting cells such as monocytes, macrophage and dendritic cells. Although, Il-16 can stimulate the expression of different pro inflammatory cytokines such as IL-1β, IL-4, TNF-α, IL-12 and IL-15(Skundric DS et al., 2015)
This study was a case-control study on 35 patient with alopecia areata and 35 case control was chosen randomly from healthy volunteers or from patients attending to the hospital or to the center complaining of dermatological diseases other than alopecia areata or autoimmune diseases or atopies. The study was carried out in the dermatology outpatient clinic in Suez Canal University hospital in Ismailia and El-Sheikh Zayed Dermatology and Venereology center from January 2017 to December 2018. This study aimed to develop a new aetiopathological mechanism in pathogenesis of alopecia areata by measuring serum interleukin 16.