الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Bladder cancer is considered as 9th most common cancers worldwide with increased incidence in old age with high prevalence in men than women. Smoking is considered as most important risk factor associated with incidence of bladder cancer, 50 patients in our study are smokers showing low median OAS and PFS comparing to non-smoker patients. Eighty to nine precent of bladder cancer patients presented with painless hematuria, dysuria, urgency and frequency, these symptoms should enhance beginning of urological screening. Transurethral resection of bladder tumor (TURBT) has an important role in accurate local staging and to minimize tumor burden for successful bladder preservation. Node positive disease carries a worse prognosis with 5-year recurrence-free survival (RFS) rates in the range of 4–35% although advancing age, pT4 stage, and positive margins are associated with worse OAS. About 75 % of newly diagnosed bladder cancers are muscle invasive. Radical cystectomy still remains the standard approach to gain high overall survival rates, although this approach has significant impact on quality of life with body shape disfiguring, surgical toxicity and loss of sexual function. Alternative approach is to use tri-modality therapy aiming to preserve native bladder with satisfying overall survival and progression free survival data. In our study patients who are underwent maximal TURBT and treated with CCRTH achieving good local tumor control.