الفهرس 
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Abstract
This study was carried out on one hundred and twenty female patients risky for pre-eclampsia (60 patients with Advanced maternal age >35 years, 60 patients with history of chronic hypertension, diabetes, kidney disease and systemic lupus erythmatosis) and forty females apparently healthy as controls. The patients were selected from Women’s Health Hospital of Assiut University Hospitals. Formal consent was obtained from patients and controls. The study was approved by Ethical Committee of Faculty of Medicine Assiut University. The following were done (for patients and control group): Medical history and clinical examination: Complete history taking and clinical examination. 2-Laboratory investigations: The following laboratory investigations were performed:Complete blood count (CBC). Random serum glucose, serum urea, serum creatinine and liver functions. 24 hour protein in urine. Serum Placental protein 13 (PP13). The current study showed the following findings: PP13 was significantly lower in patients developed pre-eclampsia in comparison to the control groupThere were significant differences between patients with chronic disease (hypertension, diabetes, kidney disease and systemic lupus erythmatosis) and control group regarding blood glucose level, urea and creatinine. There was no significant differences between patients with advanced maternal age and control group in Hemoglobin level There was no significant difference in liver functions in patients when compared with control group. 24 hour protein in urine was within normal range in patients in first trimester then increased when pre-eclampsia developed.