الفهرس 
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Abstract
This prospective study of 40 eyes of 40 patients with microbial keratitis admitted in Mansoura ophthalmic center over a six-month period. Patients were not considered for this study if they had concomitant endomphthalimitis, corneal perforation and descemetocele or Noninfectious keratitis as chemical, thermal or autoimmune keratitis. Every patient was submitted for complete ophthalmic examination and corneal scraping. Follow up of the patients was every other day after commencement of therapy till the first week then on a weekly basis till the patient was discharged. In each visit the patient was examined for size of corneal ulcer and infiltration, anterior chamber reaction or hypopyon and visual acuity. This study was conducted to evaluate the role of risk factors, clinical presentation and microbial profile on the outcome of infectious keratitis. In this study, ocular trauma was the most common predisposing factor in the previous ocular history, blepharitis & dry eye was the second most common relevant history in 10 cases (25%) followed by use of topical steroids in 4 cases (10%) and Exposure Keratopathy in 2 cases (5%). The following were reported in 1 case for each; LASIK, Entropion and CL wearing. DM and combined DM& HTN were the most common predisposing factors in systemic history in 5 cases for each (12.5%), followed by Rheumatoid Arthritis in 2 cases (5%) and drug addict in only 1 case (2.5%). There were no statically significant association between the presence of risk factors in previous history and the outcome of treatment except for Exposure Keratopthy which showed high statistically significance (p=0.27). The microbiological profile (microscopy and culture & sensitivity) had no significant effect on the treatment outcome of microbial keratitis. Clinical picture of microbial keratitis (infiltration, ulcer and anterior chamber reaction) had no significant effect on the treatment outcome of microbial keratitis except for the depth of infiltration which showed highly statistically significant association with the outcome of treatment (p=0.006). Regarding the isolated organisms in this study, 13 cases (32.5%) had positive culture of Staph aureus and 16 cases (40%) had positive culture for Aspergilus.