الفهرس 
Seizures & EpilepsyOnly 14 pages are availabe for public view
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Abstract
Objectives: We aimed to detect fatigue in epileptic patients, assess its degree and possible predictors.
Methods: An analytic observational cross-sectional study conducted on 70 epileptic patients and 30 control subjects. Inclusion and exclusion criteria were exercised to exclude older patients and any factor affecting the performance or understanding of the questionnaires. Epileptic patients were subdivided into 3 subgroups, controlled subgroup, uncontrolled subgroup and poorly controlled subgroup. Fatigue severity scale (FSS), neurological disorder depression inventory for epilepsy (NDDIE), generalized anxiety disorder 7 scale (GAD-7), Patient-reported outcomes information system sleep disturbance and sleep related impairments (PROMIS-SD and PROMIS-SRI) and Pittsburgh sleep quality index (PSQI) were used. Statistical SPSS 20.0 software and Microsoft excel were used for statistical analysis (P ≤ 0.05).
Results: from 70 patients included in this study males were 42 (60%) and females were 28 (40%). Mean of age was 31.34%. 44 (62.9%) of patients were married while 26 (37.1%) were single. Of them 37 (52.9%) were employed and 33 (47.1) were un-employed. 32 (45.7%) patients were educated while un- educated were 38 (54.3%). Fatigue scores of the epileptic group had high statistically significant difference than control group. Also, the scores of epileptic patients regarding NDDI-E, PROMIS-SRI, PROMIS-SD and PSQI had high statistical significance than control group. There was no statistical difference between epileptic group and control group in GAD-7 scores. FSS scores of uncontrolled sub-group had high statistical difference with all other groups (control group, controlled sub-group and poorly controlled subgroup). Also, FSS scores of poorly controlled subgroup had high statistical difference with both control group and controlled subgroup. There was no statistical difference between FSS scores of controlled sub-group and control group.
Conclusion: The complaint of fatigue is common in epileptic patients and the degree of fatigue was higher in adult epileptic patients than in healthy adults. Fatigue can be more severe in epileptic patients and it can even worsen the incidence of seizures. There is a vicious cycle between sleep-related problems and seizure control. Seizures are likely a primary cause of sleep-related problems, and sleep-related problems may aggravate seizure control states. Depression caused by poor seizure control may ultimately make patients feel more fatigued, and the resulting fatigue may precipitate seizures.