الفهرس 
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Abstract
This work was done to study the clinical signs and pathological changes in some organs (liver, kidney, spleen, Bursa of Fabricius and intestine) of broiler chickens (Cubb breed) fed on contaminated ration with aflatoxin B1 (AFB1) or ochratoxin A (OTA) for 36 day. Study the protective effects of either cholestyramine or oxihumate in ameliorating the toxicity via evaluation the pathological lesions, some immunohisto-chemistry markers and tissue residues of both AFB1 and OTA). So in this aspect, the work was conducted on using one hundred and forty-four healthy, one-day-old commercial broiler chicks (cubb breed) which were purchased from Alkahira Poultry Company and kept under standard hygienic conditions. The broiler chicks equally divided into nine equal groups, each of sixteen chicks. group (1): Chicks were given ration contaminated with 2 ppm AFB1/kg ration for the whole of the experimental period. group (2): Chicks were given 2 ppm AFB1 /kg ration together with chemical detoxifying agent cholestyramine (170 µg/ mg aflatoxin in the ration) (340 µg/ kg ration) for the whole of the experimental period. group (3): Chicks were given 2 ppm AFB1/kg ration together with physical detoxifying agent oxihumate (3.5 g/kg ration) for the whole the experimental period. group (4): Chicks were given ration contaminated with 100 ppb OTA/kg ration for the whole the experimental period. group (5): Chicks were given 100 ppb OTA/kg ration together with chemical detoxifying agent cholestyramine (170 µg/mg ochratoxin) (17 µg/kg ration) for the whole of the experimental period. group (6): Chicks were given100 ppb OTA/kg ration with physical detoxifying agent oxihumate (3.5 g/kg ration) for the whole of the experimental period. group (7): Sixteen chicks were divided equally into two sub-groups with 8 chicks each and were given chemical.