الفهرس 
InfertilityOnly 14 pages are availabe for public view
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Abstract
The major causes of infertility include ovulatory dysfunction (15%),tubal and peritoneal pathology (30-40%), and male factors (30-40%), uterine pathology is generally less common, and the rest is largely unexplained.Unexplained infertility is diagnosed when all of the standard elements of the infertility evaluation yield normal results. IUI has been used to treat infertile couples for years and it is an accepted form of treatment of unexplained infertility. Empiric ovarian stimulation with clomiphene citrate, aromatase inhibitors (Letrozole) or exogenous gonadotropin is commonly combined with IUI in the treatment of couples with unexplained infertility.Gonadotropins are associated with more effective ovulation induction and higher pregnancy rates than clomiphene citrate, but are expensive and carry higher risks for OHSS and multiple pregnancies. Clomiphene citrate has many side effects especially thick cervical mucus and thin endometrium.Accordingly, new agents are needed to overcome these above side effects.So, we investigated letrozole as a new ovulation-inducing agent.This study was conducted aiming to compare IUI after controlled ovarian hyperstimulation by HMG protocol versus IUI after controlled ovarian hyperstimulation by HMG combined with letrozole as regards duration of stimulation days, number of cycles of induction, number of mature follicles and size of follicle at day of HCG administration,endometrial thickness at day of HCG administration and clinical pregnancy rate.