الفهرس | Only 14 pages are availabe for public view |
Abstract During the search for promising bioactive secondary metabolites from microorganisms, Streptomyces sp. IOPU, Nq.53 and Nq.72 drew our attention. The sponge Iotrochoto purpurea derived Streptomyces sp. IOPU produced seven diverse bioactive compounds: hexahydro-menaquinone MK-9 (I), linoleic acid (II), methyl linoleate (III), borrelidin (IV), ferulic acid (V), N-acetylanthranilic acid (VI) and sitosteryl-3β-D-glucoside (VII). The marine sediment derived Streptomyces sp. Nq.53 produced six diverse bioactive compounds: N-acetyl tryptamine (VIII), indole acetic acid (IX), indole carboxylic acid (X), 5-(N-acetyl)-pent-2-one (XI), indole acetic acid methyl ester (XII) and β-sitosterol-3-D-glucoside (XIII). Furthermore, Streptomyces sp. Nq.72 isolated from Nerium oleander produce four bioactive compounds: anthranilic acid (XIV), tryptophol (XV), gleceryl linoleate (XVI), 3-hydroxy acetyl indole (XVII). Structures of the obtained compounds were assigned by intensive studies of their NMR (1 H, 13C & 2D NMR) mass spectrometric means. In this study, taxonomical characterization, and fermentation of the microbial sources, followed by structural determination of the obtained metabolites were reported together with their antioxidant, antimicrobial, and cytotoxic activities. The cytotoxic activities of extracts and isolated compounds were tested against KB-3-1, KB-V1, colorectal Caco-2 and breast MCF-7 cell lines. The antimicrobial activity was tested against a set of microorganisms. |