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Abstract Background: Carcinoma of the breast is the commonest cancer in female and the second most cause of death in cancer related deaths. Aim of the work: to overview the different prognostic factors in breast cancer in our patients with breast cancer. Patients and Methods: This retrospective study was conducted on 100 patients undergoing mastectomy or breast conservative surgery at El-Demerdash University Hospital. Clinico-pathological features including age, weight, family history, axillary lymph node status, tumor size, pathology result will be reviewed. Results: Axillary lymph node status shows a significant association between the grade of LN and the development of recurrence in group N3 patients compared with N, N1 and N2 groups. there is variability in disease-free survival among the ER/PR Her2 subtypes within the first 3 years following diagnosis after receiving the treatment. While probability of free from disease was best for the ER+, PR +or-/ Her2 – subtype followed by ER- PR-/ Her2 – (71%) and (50%) respectively. On the other hand all patients in subtypes ER+, PR +or- / Her2 + and ER- PR - / her2 + subtypes suffered from recurrence of disease. In Conclusion, we have found that the extent of nodal involvement and hormone receptor expression are very important prognostic and predictive factors in breast cancer management and recurrence. |