الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Renal failure (RF) has significantly increased in developing countries such as Egypt. Associations exist between chronic kidney disease (CKD) and environmental exposures may be modulated by genetic susceptibility and other comorbid conditions and may lead to the development of RF. Transforming growth factor - pi (TGF-pl) is a cytokine involved in the process of pathological tissue sclerosis, which is part of the pathophysiological mechanism of RF development. The aim of the study was to identify the correlation between polymorphism of TGF-pl and environmental exposure in RF patients. Methods: Self-developed structured questionnaire was designed to assess the health status. Role of the transforming growth factor- pi (TGF-pl) gene polymorphisms located at codons 10 polymorphism detection was done by amplification refractory mutation system method. A case control study was done for 60 hemodialysis cases and 30 healthy control from Borg El Arab town, Alexandria, Egypt.
Results: There were significant differences between the two studied groups according to age, marital status, educational level, job, working area, physical activity, eating habits, drinking tap water and biochemical tests except sodium. Also, there were significant differences between the two studied groups according to genotypes.
Conclusion: Results suggested that environmental factors and TGF-pi polymorphisms may play a role in increasing the risk of development of RF.