الفهرس 
Liver ................................Only 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is the most common primary liver cancer
comprising 75%-85% of cases of liver cancer. It is the sixth most common cancer and
the second leading cause of cancer deaths worldwide. HBV and HCV are major
causes of viral hepatitis that lead to the development of cirrhosis and HCC.
Livin is a novel member of the IAP family, which has two splicing variants
that contain open reading frames of 298 and 280 amino acids.
Livin is not expressed or low expressed in most of terminal differentiated tissues
of normal adults, but highly specific overly expressed in certain malignant tumors, such
as esophageal cancer, gastric cancer, liver cancer, intestinal cancer, prostatic cancer,
bladder cancer, renal carcinoma, lymphadenoma, neuroblastoma and leukemia.
Yes-associated protein (YAP or YAP1) is an oncoprotein encoded by the YAP
gene in the human chromosome 11q22. YAP is one of the downstream proteins in the
Hippo signaling pathway.