الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Colorectal cancer (CRC) represents the 9% of all malignancies and is considered as an important cause of death worldwide. TLRs belong to the pattern recognition receptors (PRRs) family. They recognize molecules broadly shared by pathogens collectively named as pathogen- associated molecular patterns (PAMPs) and microbe-associated molecular patterns (MAMPS), the latest usually expressed by resident microbiota. Toll-like receptors are an important regulator of immune response, wherein polymorphisms and expression patterns of one of the TLRs, TLR4, serve as an influencing factor towards cancer susceptibility, proliferation, differentiation, metastasis, prognosis, and overall patient survival. Aim of the work: To assess the possible association between the polymorphism in TLR4 gene and the susceptibility to colorectal cancer which might help in early diagnosis and the treatment of the disease. We concluded that; Our results suggest that TLR4 gene polymorphism (rs498670) and (rs 10759932) is not a key modulator of the risk of developing colorectal cancer in Egyptian patients. Colorectal cancer (CRC) represents the 9% of all malignancies and is considered as an important cause of death worldwide. TLRs belong to the pattern recognition receptors (PRRs) family. They recognize molecules broadly shared by pathogens collectively named as pathogen- associated molecular patterns (PAMPs) and microbe-associated molecular patterns (MAMPS), the latest usually expressed by resident microbiota .
Toll-like receptors are an important regulator of immune response, wherein polymorphisms and expression patterns of one of the TLRs, TLR4, serve as an influencing factor towards cancer susceptibility, proliferation, differentiation, metastasis, prognosis, and overall patient survival. Aim of the work: To assess the possible association between the polymorphism in TLR4 gene and the susceptibility to colorectal cancer which might help in early diagnosis and the treatment of the disease. We concluded that; Our results suggest that TLR4 gene polymorphism (rs498670) and (rs 10759932) is not a key modulator of the risk of developing colorectal cancer in Egyptian patients.