الفهرس 
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Abstract
Summary
Head lice infestations cause social problems for the infected, including embarrassment and misunderstanding. Head lice infections cause skin irritation, pruritus and occasional secondary bacterial infection from scratching. Treatment of head lice is difficult due to resistance which made insecticide treatments ineffective and the only alternative treatment was the physical removal of lice.
In this study, our aim was to assess the effect of TiO2 nanoparticles, Ivermectin and ivermectin-loaded TiO2 on head lice in vitro. This study was conducted on 50 patients infested with head lice from Beni-Suef Governorate. These patients were from all age groups and from both gender.
The infested subjects distributed as (13) males and (37) females (26% versus 74%), their ages was ranged from (5) to (72) with an average age of (26.84 ±19.3) years old. The study participants were mostly rural residents (34), while only about (16) were urban residents (68% versus 32%). While for the social level of the study participants; the majority of studied participants were low socioeconomic level (37) and about (13) were moderate socioeconomic level (74% versus 26%). Regarding number of family members, It was ranged from (3) to (11) with an average of (6.42 ±1.9) family member.
The results showed that the percent mortality effects of topical ivermectin 0.2% and 0.5% were 86% and 94% respectively, against adult head lice, while 88% and 94% respectively, against head lice larva.
As regarding the effect of TiO2, the percent mortality effects of synthesized TiO2 NPs were 34, 58 and 100 at 2, 6, and 10 mg/L, respectively, against adult head lice, while average percent mortality for synthesized TiO2 NPs was 40, 68 and 96 at 2, 6, and 10 mg/L, respectively, against head lice larva.
when the ivermectin (0.2% and 0.5%) is loaded on TiO2 10mg/L respectively, the percent mortality effects were 94% and 100% respectively for adult head lice, while 92% and 94% respectively for head lice larva.
According to Spearman’s rank correlation; by increasing the concentration of drug, the percentage of died lice (adult and larva) was increased. There was a significant moderate positive correlation between concentrations of Ti O2 and percentage of died lice (r= 0.526, p-value= 0.001). On the other side the correlation between (Ivermectine concentrations) and (Ti O2 10mg/L ivermectine) showed non-significant correlation, but value of correlation coefficient (r) and its direction was recorded for screening purposes.