الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 170 |  |  |
| | | from | 170 | | |
Abstract
Peptic ulcer is one of the most common digestive disorders, as it affects approximately 10% of the world’s population. Ibuprofen is used as a strong analgesic and anti-inflammatory, as well as the first drug in the treatment of rheumatoid arthritis. But like other non-cortisone-derived anti-inflammatory drugs, using ibuprofen for long periods may lead to severe side effects on the digestive system, especially ulceration. Many drugs have been used to treat stomach and duodenal ulcers, such as histamine 2 receptor antagonists and protein pump inhibitors, but they were not effective enough and caused Therefore, there was a need for a new, safer alternative for treating stomach ulcers. The aim of the current study was to compare the therapeutic effect of mesenchymal stem cells derived from bone marrow and histamine receptor 2 antagonists on the healing of stomach ulcers induced by ibuprofen. This study was conducted on a number of Fifty adult male white mice. Ten mice were used to obtain mesenchymal stem cells derived from the bone marrow, while forty mice were divided into four groups, where each group consisted of 10 mice. The first group represented the control group, and it was divided into the first subgroup A (negative control group) which is not administered. Any medication. And the first subgroup B (positive control group) was given a 1% sodium carboxymethylcellulose solution daily by gastric tube for 6 consecutive days and then sacrificed, the second group represented the ibuprofen group or the stomach ulcer group. These mice were fasted for 24 hours and then they were made Stomach ulcers by administering 200 mg / kg ibuprofen once daily suspended in a 1% sodium carboxymethylcellulose solution by gastric tube. After 6 consecutive days of treatment, these mice were sacrificed for examination of stomach tissue. The third group represents the group of stomach ulcers treated with nizatidine: These mice underwent a stomach ulcer as in the second group, and then they were treated with nizatidine at a dose of 31.25 mg / kg given once daily by mouth via a gastric tube. After 6 consecutive days of treatment, these mice were sacrificed. The fourth group represents a group of stomach ulcers treated with mesenchymal stem cells: These mice underwent a stomach ulcer as in the second group, and after the occurrence of stomach ulcers, they were injected with stem cells derived from bone marrow at a dose of (3 × 106) in the tail vein. A week after the stem cells were injected, the mice were sacrificed.