الفهرس 
Coronary vascular disease:
TheophyllineOnly 14 pages are availabe for public view
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Abstract
Contrast-induced nephropathy (CIN) is a common complication of percutaneous coronary intervention (PCI). Increased release of adenosine and stimulation of adenosine receptors have been proposed to be major mechanisms in the development of CIN. The primary goal was the assessment of CIN. The secondary goal was the assessment ability of Neutrophil-gelatinase associated lipocaline (NGAL) in early detection of CIN. Fifty nine patients with stable serum creatinine and having moderate or high risk for CIN were randomized to three groups: group I (received IV hydration 1 ml/kg/hr for 24 hours plus N-acetylcysteine (NAC) 600 mg bid two days before PCI), group II (received IV hydration 1ml/kg/hr for 24 hours plus Theophylline 200 mg in 100 ml 0.9% saline, as IV infusion 30 minutes before PCI), and group III ( received IV hydration 1 ml/kg/hr for 24 hours plus NAC 600 mg bid two days before PCI plus Theophylline 200 mg in 100 mL 0.9% saline, as IV infusion 30 minutes before PCI). Blood sample was taken to measure SCr, BUN and NGAL pre and post PCI. The incidence of CIN was significantly lower in group III compared with other groups. NGAL Sensitivity was 100%, Specificity was 80%, and area under the curve equal 0.92. Our study showed that, the use of Theophylline plus NAC in patients undergoing elective PCI lead to decrease the CIN incidence. The use of NGAL is useful early biomarker in detection of CIN due to high specificity and sensitivity.
Keywords: NAC;NGAL;PCI;CIN;SCr;Theophylline