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Abstract Summary Preeclampsia is a major contributor to maternal mortality worldwide and remains a leading cause of perinatal mortality and morbidity, complicating 3–8% of pregnancies. It is characterized by an elevated blood pressure and proteinuria, which develops after 20 weeks of gestational age. The cause of preeclampsia is still unknown but Vasospasm or increased vascular reactivity and endothelial cell dysfunction may be the final common pathway of several different pathophysiologic mechanisms. Vitamin D deficiency in the pregnant women has been associated with adverse pregnancy outcomes, such as gestational diabetes mellitus (GDM), small for gestational age (SGA) The objective of this study was to investigate whether there is an association between maternal serum 25-hydroxy vitamin D3 (25(OH) D) levels during pregnancy and the risk of Preeclampsia. An observational comparative study was conducted upon 106 pregnant women who attended antenatal outpatient clinic or admitted in Obstetrics Department of Tanta University 24-34 weeks of gestation. The participating women were divided into two equal groups: group A (control group: 53 cases): Apparently healthy pregnant women. group B (patients group: 53 cases): Preeclamptic pregnant women. The group was subdivided according to the severity of preeclampsia into mild and severe with |