الفهرس 
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Abstract
Objectives: This study was conducted to evaluate the biological effects of adipose derived stem cells (ADSCs) seeded onto coral granules on healing of surgically induced mandibular bone defects in albino rats. Materials and Methods: Bone defects were created in the diastema region of fifty four healthy male albino rats and then divided into three groups. group I (n=18) (control) rats, the bone defects were left to heal spontaneously. group II (n=18) (coral) rats, the bone defects received coral only. group III (n=18) (coral/ADSCs group) rats, bone defects were filled with coral granules seeded by 0.25×10 6 ADSCs. Rats were euthanized at 1, 4 and 8 weeks’ time points. Their mandibles were surgically removed and processed for histological and histomorphometric assessments. Results: Control group showed normal stages of bone defects healing. While, coral group showed greater amount of regenerated bone trabeculae. Coral/ADSCs group showed marked enhancement in bone healing detected by the increased trabeculation, maturation and proper connectivity of newly formed bone trabeculae. Statistical analysis revealed significant increase in collagen fibers and calcium deposits in coral/ADSCs group when compared to control and coral groups particularly at 4 weeks’ time points. Conclusions: The results suggest enhanced regeneration of bone when coral granules were used locally to treat surgically-induced mandibular bone defects in rats. However, ADSCs seeded onto coral granules even revealed better results than coral alone and its use may be an effective therapy for treatment of bone defects that needs further investigations in human.