الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Pressure ulcers are the third most expensive disorder after cancer and cardiovascular diseases. The development of a pressure sore has been considered a marker for care quality, as they are potentially preventable, a Pivotal cause of death for inpatients, and is a cause of patient’s discomfort, prolonged hospital stay and, in some cases, death.
“Prevention is better than cure” is the best match with the case of pressure ulcer, as it can be totally prevented with the compassionate dedicated care of the patients.
Platelet-rich plasma (PRP) therapy has been recently rising as a potentially treatment choice for numerous clinical applications and has been used in chronic wounds for its beneficial effects. The large quantities of cytokines, autologous growth factors as well as other mediators in PRP which are sustainably released in addition to the mesenchymal mononuclear cell profile of PRP may boost wound healing and help in chronic inflammation resolution. Platelets promote these effects through degradation, in which these growth factors(platelet-derived GF (PDGF), transforming GF-β1 (TGF-β1), vascular endothelial GF (VEGF), basic fibroblastic GF (bFGF), and epidermal GF (EGF)) are released from alpha granules.
The aim of the study was to determine the relative efficacy of autologous platelet-rich plasma in the treatment of skin ulcer grade three compared to standard care.
This study was carried out on 28 Patients who were admitted to the Critical Care Medicine Department at the Alexandria University Hospital. All patients were divided into two groups. The intervention group (group A) received treatment that included PRP injections, conventional debridement, regular repositioning and dressing with saline and betadine. The control group (group B) were subjected to conventional debridement, regular repositioning and dressing with saline and betadine without PRP injections.
The ulcers of both groups will be first debrided to remove any necrotic tissue and based on the wound size and area, then the PRP preparation will be injected four times at a weekly interval to the ulcers of patients of group A. The PRP will be injected subcutaneously inside and around the periphery of the wound/ulcer by 0.1ml at 1 cm intervals.
The basic characteristic of the patients in the two groups included complete blood picture, ulcer volume area and ulcer surface area. The random distribution of the patients in the two groups show a symmetrical data to eliminate the effect of on admission data on the net outcome, especially the ulcer size.
In our results, there was a significant decrease in ulcer surface area in group A from the second week till the end of follow up, while in group B the improvement in ulcer surface area was noticed at the fourth week, while in comparing the two studied groups regarding the ulcer surface area it was found a significant improvement in group A more than group B from the first week till the fourth week