الفهرس 
Abstract
Cytotoxic and anticancer activities of isatin derivativesOnly 14 pages are availabe for public view
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Abstract
The thesis is prefaced by a brief literature survey on indole-2,3-dione and 1,3-thiazol derivatives as potential anticancer scaffolds in addition to a brief summary on cell cycle process and importance of the checkpoints enzymes as targets for anticancer agents. The thesis involved design and synthesis of two series of (Z)-3-substituted-2-(((E/Z)-5-substituted-2-oxo-1-substituted-indolin-3-ylidene)hydrazin- ylidene)thiazolidin-4-ones,4(a-s) and (E/Z)-1-substituted-3-(((Z)-3-substituted-4-methylthiazol-2(3H)-ylidene)hydrazineylidene)-5-substituted-indolin-2-ones, 5(a-s). The targeted derivatives were obtained by three steps synthetic reaction. The first step is the N-propylation or N-benzylation of isatin to afford N-substituted-isatins 2(a-f). The second step is formation of isatin-3-(Z)-thiosemicarbazones 3(a-r), the key intermediates for the targeted derivatives.