الفهرس 
ThalassemiaOnly 14 pages are availabe for public view
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Abstract
Summary Thalassemia is the commonest hereditary hemoglobinpathies resulting from significantly reduced or absent synthesis of normal hemoglobin.β-thalassemia is an autosomal recessive hereditary blood disordercharacterized by reduced or absent beta globin chains synthesis. Although the prognosis for patients with thalassaemia had greatly improved by early diagnosis and regular blood transfusion and chelation therapy but frequent blood transfusions have been associated with iron overloadwhich is the responsible for most of complication of thalassemia due to deposition of it in different tissueswhich may result in multiple endocinological problems as impaired glucose tolerance,DM, hypothyroidism ,hypogonadism . The aim of this work is toevaluate β-cell function, Insulin resistance and glucose metabolism abnormalities in β- Thalassemia major patients. The current study was carried out onThirty (30) child with packed RBcs transfusion dependant β-Thalassaemia Major who were admitted in Hematology Unit, Pediatric Department, Tanta University Hospital and Twenty (20) healthy child of matched age and sex as a control. For all children, the following were performed: 1- History taking. 2- Thorough clinical examination. 3- Laboratory investigations including : - Oral glucose tolerance test at o and 2 hour post intake of 1.75g/kg of glucose (18).