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Abstract Preeclampsia is the most common and serious complication of the pregnancy that is a major cause of maternal and fetal morbidity and prenatal mortality.Preeclampsia is a pregnancy specific multisystem disorder. It is characterized by new onset of hypertension(blood pressure ≥140/90 mm Hg in previously normotensive women after the 20th week of pregnancy) and proteinuria (≥300 mg/24hr urine collection).Various biochemical and biophysical screening markers to predict the occurrence of preeclampsia have been tested. Neurokinin B (NKB), a neuropeptide of the tachykinin family, is considered one of these possible factors released by the developing placenta.The present study was conducted to evaluate plasma levels of Neurokinin-B in pre eclampstic and normotensive pregnant women at(20-38) weeks of gestation and correlate the levels of Neurokinin-B to the severity of pre eclampsia.This study is a cohort prospective study. The study participants were consisted of 90 pregnant women during their gestational age(20-38weeks)attending outpatient clinic and∕ or inpatient department of Obstetrics& Gynecology at Tanta University Hospitals. |