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Abstract In the current study, using a two-step synthesis, new thalidomide dithiocarbamate compounds were synthesized and some of them tested for their cytotoxic activity against human cell line, these new tested compounds may be formulated as inhaler due to their better physicochemical properties (particle size) than other synthesized compounds. The synthesis of target compounds is summarized in scheme A and B via a two-step synthesis method. In the first step thalidomide 1 was reacted with sodium hydride and 1, 2 dichloroethane or 1, 3 dichloropropane or chloroacetyl chloride in dimethyl formamide to obtain chloroethyl thalidomide 137, chloropropyl thalidomide 138 and chloroacetyl thalidomide 139 respectively in a reasonable yield (52 % or 54 % or 59 %). |